SUMMARY:
Powerful antioxidant
 
Antioxidant action
Anti estrogenic effect
improves cardiovascular health
reducing LDL (bad cholesterol)
Cancer Prevention
increases endurance
elevates metabolism (29% versus 10% caffeine)
Red wine more than ever "to your health!''
 
The consumption of red wine dates back thousands of years. Over time this drink made history and still fascinates mankind. The discovery of wine quickly raises passions through countless varieties, textures, tastes and aromas. There is no other beverage that can make us travel all around the world and when you listen to the description of a great wine made by a sommelier can quickly believe of poetry. Yet all this is only a part of all the fine qualities of this exciting elixir.
 
Beyond its taste attributes and festive red wine of exceptional therapeutic properties!
 
It all started with what we call today the'' French paradox''. This situation for the least surprising raised many questions among scientists. How was it possible that France cardiovascular disease is much less present than us in North America? With a power far from being perfect the French enjoy a cardiovascular far superior to us in North America?
 
There was enough for scientists seeking a logical and accurate response to this situation. Research quickly led to the discovery of a class of polyphenol stilbenes leresvératrol. Resveratrol is found mainly in the skin of grapes and its concentration can vary from one grape variety to another.
 
Cardio-vascular diseases
 
Many studies have shown that resveratrol has the ability to influence a variety of physiological targets responsible for the development of dozens of chronic and degenerative diseases. For example, resveratrol reduces the risk of cardiovascular disease by preventing the development of atherosclerotic plaques in the walls of arteries and other blood and by promoting better dilation of these vessels vessels. More resveratrol prevents oxidation of LDL (bad cholesterol) and increases the body's ability to produce HDL (good cholesterol).
 
Cancer
 
Resveratrol also has remarkable anti-cancer properties including a triple action: fight against the formation of free radicals, it protects DNA from damage caused by chemicals and neutralize carcinogens in the liver. A study published in the journal "Science" showed that polyphenol is active in all three phases of tumor development (initiation-promotion-progression). Resveratrol kills cancer whether or not estrogen dependent cells and blocks the development of bone metastases in some cancers. Other studies have shown that it possible to improve the results of chemotherapy as resveratrol protects healthy cells of some adverse effects of chemotherapy.
 
The Italian research has shown a significant reduction in the growth of breast cancer cells exposed to resveratrol. This effect is caused by a sharp decrease in the expression of estrogen receptors, often involved in the progression of breast cancer receptors. More importantly these studies demonstrate that resveratrol abolishes the growth of cells resistant to tamoxifen, a drug often used to treat breast cancer hormone-dependent. These results could be used to develop anticancer agent for patients resistant to hormonal therapy.
 
Resveratrol exerts its dramatic anti-estrogenic activity by preventing the most powerful endogenous estrogen from binding to estrogen receptors. It is part of a family of molecules called SERMs (specific, estrogen, receptor, modulator). The agonist and antagonist activity of resveratrol on estrogen receptor alpha is significant, but its affinity for these receptors is much weaker than estrogen itself. In other words resveratrol can bind to receptors effectively enough to prevent the more powerful and toxic metabolites exert their effects of estrogen. A decrease in the expression of estrogen leads to many women in a significant reduction of water retention and cellulite.
 
Obesity
 
Recent research has also shown that resveratrol can help prevent the accumulation of fat and prevent the development of obesity.
 
Resveratrol targets a protein called sirtuin that mimics the effect of calorie restriction on fat cells. German researchers have also published work showing that resveratrol can have a direct effect on body weight by interfering with the accumulation of fat in fat cells. Using immature adipocytes as a model, they found that the addition of resveratrol prevented these cells to mature, reducing their susceptibility to proliferate and increase in volume. The combined effects of resveratrol therefore promote a significant reduction in body fat.
 
Other research on obese mice have shown that when large amounts of resveratrol were added to their diet, general health status of these is improving dramatically. Their insulin levels decreased thus preventing the onset of diabetes. Liver damage and heart caused by excessive calorie diets have also regressed significantly. The life expectancy of obese mice treated with resveratrol compared to mice to normal weight control group.
 
Muscle activation
 
French researchers tested resveratrol in animals placed in conditions of extreme inactivity to observe whether the administration of resveratrol could help in situations to prevent muscle atrophy. The results were amazing! Simple administration of resveratrol to these animals was sufficient to preserve the mass and the metabolic activity of muscle cells. Cells also retained their sensitivity to insulin.
 
According to Johan Auwerx of the Institute of Genetics, Molecular and Cellular Biology in Illkirch, France, "Resveratrol increases muscle endurance by increasing the components of energy production in muscle cells." Auwerx said:
 
High doses of trans-resveratrol are required to trigger the path that gives more mitochondria in cells.'' The effects of resveratrol are so pronounced that endurance athletes may one day take resveratrol as ergogenic agent to increase their performance ' 'he concludes.
 
The downside!
 
As nothing is perfect, the amount of resveratrol required to promote weight loss are important. It takes more than 100 bottles of red wine a day to get the amount of resveratrol needed to have the same effect observed by mice. So for weight loss supplementation is the only option.
 
Resveratrol supplementation is now possible. On the market there are several products containing different sources of this impressive polyphenol.
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